I obtained master degree in physical Chemistry from Calcutta University. Then shifted to biophysics and obtained Ph.D degree from Molecular Biophysics Unit (MBU) at Indian Institute of Science, Bangalore on “Computer modelling studies on G-rich unusual DNA structure”. Subsequently, entered into protein folding field and worked as postdoctoral research fellow in the department of Chemistry and Biochemistry, University of Delaware, USA for three years.

Course page

Courses taught / teaching/Planning to teach

• Introduction to Bioinformatics
• Laboratory
• General Biology
• Measurement Techniques – I
• Protein modelling
• Biomolecular conformation
• Biophysics

Research Interest

         At present (from 2004), I'm working as Assistant Professor in the Biological Sciences Group, BITS, Pilani. My research interests include computational molecular biophysics, analyses of biomolecular structures and structure-function relationship using model building and computational techniques, elucidation of protein folding problem, Protein-DNA interactions and modelling of RNA structures, data base analysis of biomolecules, biomolecular structure prediction. I’m also interested in structural bioinformatics.

Ongoing project

"In-silico Characterization of Non-native Structural Ensembles of Small Proteins and Peptides and Its Implication on Protein Folding and Misfolding Processes"--- Funded by DST

SELECTED RECENT PUBLICATIONS

1.         Breaking non-native hydrophobic clusters is the rate-limiting step in the folding of an alanine-based peptide (Shibasish Chowdhury, Zhang W., Wu C., Xiong G. M. and Duan Y.), Biopolymers 68, 63-75 (2003).

2.         Ab initio folding simulation of the Trp-cage mini-protein approaches NMR resolution (Shibasish Chowdhury, Lee M. C., Xiong G. M., Duan Y.), J. Mol. Biol. 327, 711-717 (2003)

3.         A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations (Duan Y, Wu C, Shibasish Chowdhury et al.) J. Comp. Chem. 24, 1999-2012 (2003)

4.         Characterizing the rate-limiting step of Trp-cage folding by all-atom molecular dynamics simulations (Shibasish Chowdhury, Mathew C. Lee, and Yong Duan) J. Phys. Chem. B  108, 13855-13865 (2004)

5.         Fs-21 Peptides Can Form Both Single Helix and Helix-Turn-Helix (Zhang, W.; Lei, H.; Shibasish Chowdhury, S.; Duan, Y.)  J. Phys. Chem. B. 108, 7479-7489. (2004)

6.         Denatured-state ensemble and the early-stage folding of the G29A mutant of the B-domain of protein A (Shibasish Chowdhury, Hongxing Lei, and Yong Duan) J. Phys. Chem. B. 109, 9073-9081 (2005)